It will be moved from being on Mondays at 8 pm after Jane the Virgin (due to Supergirl moving from CBS to The CW to after The Vampire Diaries on Friday at 9pm before The Originals will return after the fall.
- Rachel Bloom as Rebecca Bunch
- Vincent Rodriguez III as Josh Chan
- Santino Fontana as Greg Serrano
- Donna Lynne Champlin as Paula Proctor
- Pete Gardner as Darryl Whitefeather
- Vella Lovell as Heather Davis
- Gabrielle Ruiz as Valencia Perez
- David Hull as Josh "White Josh" Wilson
- Steve Monroe as Scott Proctor
- Parvesh Cheena as Sunil Odhav
- Yael Grobglas as Trina
- Brittany Snow as Anna Hicks
- Albert Tsai as Xiao Wong
- Scott Michael Foster as Nathaniel
- Erick Lopez as Hector
- Johnny Ray Meeks as Kevin
- Jacob Guenther as Chris
- Amy Hill as Lourdes Chan
- Gina Gallego as Mrs. Hernandez
- Burl Moseley as Jim
- Michael McMillian as Tim
- Michael Hyatt as Dr. Noelle Akopian
- Stephnie Weir as Karen
- Robin Thomas as Marco Serrano
- Rene Gube as Father Brah
- Esther Povitsky as Maya
- Thor Knai as Xander
- Eugene Cordero as Alex
- Jayden Lund as Guardrail
- Danny Jolles as George
- Paul Welsh as Trent Maddock
- Olivia Edward as Madison Whitefeather
- Steele Stebbins as Tommy Proctor
- Alberto Isaac as Joseph Chan
- Tess Paras as Jayma Chan
- Coryn Mabalot as Jastenity Chan
- John Allen Nelson as Silas Bunch
- Gabrielle Ruiz is promoted to a series regular as Valencia Perez after being a recurring member.
- Season 2 will be having Spice Girls, Disney and Beyonce inspired musical numbers according to sources.
- Confirmed by Rachel Bloom,there will be a parody of Beyonce's "Lemonade "
- Reportedly there will be a Spice Girls tribute number.
- Paula Proctor (Donna Lynne Champlin) will be featured in a Disney inspired number.